Cardiology Letters 2020, 29(2):93-96

CLARIFY registry - five-years follow-up of patients with chronic coronary syndrome

Murín J

I. interná klinika LFUK a UNB, Nemocnica Staré Mesto, Bratislava, Slovenská republika

Coronary artery disease (CAD) is one of the most common and serious cardiovascular (CV) diseases in the developed countries. Last year there was a change in the classification of CAD presented at the ESC Congress, 2019. The dynamic nature of the CAD process results in various clinical presentations, which can be categorized as either acute coronary syndromes (ACS) or chronic coronary syndromes (CCS). Stable CAD has been renamed to Chronic Coronary Syndrome (CCS). CLARIFY registry (32 703 patients with CCS from 45 countries) was a prospective observational registry (starting Nov 2009 - Jun 2010 with 5-years follow-up) and its data were analyzed: a) Primary outcome endpoint (CV mortality/nonfatal myocardial infarction, MI) rate was 8.0% (male: 8.1% and female: 7.6%), b) Cox proportional hazards model showed main independent predictors of primary end-point: prior hospitalization for heart failure, current smoking, atrial fibrillation, prior MI and stroke, diabetes, current angina and peripheral artery disease. c) There was an interaction between angina and prior MI. Among patients with prior MI was angina associated with higher primary event rate (11.8%) versus (8.2%) in patients without angina. Among patients without prior MI were event rates similar for patients with (6.3%) or without (6.4%) angina. Prescription rates of evidence based secondary prevention therapies were high. Patients with both angina and MI are in a high-risk subgroup and these patients need intensive treatment.

Keywords: chronic coronary syndrome; myocardial infarction; angina pectoris; cardiovascular mortality

Published: February 1, 2020  Show citation