Cardiology Letters, 2015 (vol. 24), issue 4

Comment on 2014 ESC/ESA Guidelines on non-cardiac surgery: cardiovascular assessment and management

Dúbrava J, Jurkovičová O, Mikla F

Cardiology Letters 2015, 24(4):217-221  

Pathological changes in cardiovascular system in long-term doxorubicin-treated rats and effect of quercetin

Dovinová I, Barančík M, Krátka D, Fogarassyová M, Kvandová M, Barteková M

Cardiology Letters 2015, 24(4):243-246  

Aims: Doxorubicin is an effective anticancer drug, but with several limitations in treatment. Application of anthracycline - doxorubicin (DOX) induces chronic pathological changes in the myocardium. The mechanisms of DOX cardiotoxicity may be multifactorial, including increased production of reactive oxygen species leading to oxidative stress, cell necrosis and apoptosis induction. Treatment with additional substances such as flavonoids can influence the negative effect of doxorubicin, and quercetin (QCT) was found as a potential preventive substance in the treatment of cardiovascular diseases. The aim of the present study was to determine the effect...

The effect of PPAR? agonist - pioglitazone on hypertension and redox regulation in young and adult SHR

Kvandová M, Krátka D, Bališ P, Barančík M, Dovinová I

Cardiology Letters 2015, 24(4):247-250  

Aim: The PPARγ is an uclear receptor that takes part in the regulation of energy homeostasis, antioxidant response and hypertension development and can be also activated using an exogenous agonist such as pioglitazone. The aim of this study was to determine the influence of pioglitazone (PIO) treatment on blood pressure (BP) and redox systems in the brainstem (BS) and the left heart ventricle (LV) and specify changes among young and adult spontaneously hypertensive rats (SHR). Methods: Blood pressure was determined by the plethysmography method. Production of superoxide radicals was detected by Lucigenin-enhanced chemiluminiscence. Quantitative...

Ambulatory blood pressure monitoring in relation to daily routine activities

Regecová V, Kellerová E

Cardiology Letters 2015, 24(4):251-256  

Objective: The aim of this study was to quantify the impact of various factors of everyday life in children, adolescents and young adults which may distort the 24-hour profile of BP, classification of hypertension and identification of non-dipping. Subjects and methods: ABPM was requested on clinical grounds for hypertension in 98 patients, aged 10-24 yrs, by physicians of the outpatient Department of Cardiology. Laboratory blood pressure (BP) measurements at rest and during a mental arithmetic test and 24-h ABPM were performed using oscillometric devices (OMRON resp. SUN-TECH). ABPM was recorded under normal everyday conditions, excluding vigorous...

Ambulatory blood pressure monitoring - indicator of blood pressure control

Gašpar Ľ, Vámosi R, Dukát A, Čaprnda M, Bendžala M

Cardiology Letters 2015, 24(4):257-260  

Objectives: Ambulatory blood pressure monitoring (ABPM) allows an insight into the values and variability of blood pressure over a defined period. The aim of our study was to analyse the logs ABPM and to comprehensively evaluate the contribution of this methodology not only in terms of blood pressure control and diurnal index setting, but also from the prognostic aspect. Methods: We analysed 206 ABPM records from patients admitted to the internal department in the calendar year 2013. 15 entries (7.3%) could not be evaluated due to an insufficient number of measurements. 93 men (45%) and 113 women (55%) were divided into 4 groups according to their...

Role of sympathetic nervous system in the pathophysiology of resistant hypertension

Škultétyová D

Cardiology Letters 2015, 24(4):226-229  

The pathogenesis of hypertension is complex and multifactorial. Increased sympathetic nervous system (SNS) activity has been documented in all hypertension stages, the more advanced the stage, the greater the adrenergic activity. The excessive SNS activity plays a crucial role in the development of resistant hypertension (RH). The autonomic NS can modulate innate and adaptive immunity and thereby influence the inflammatory response. The sympathoexcitation and the neuro-immune pathways may increase the initiation or acceleration of pathological processes. Obesity and salt sensitivity are important environmental risk factors in hypertension. Both factors...

Strategy of combination antihypertensive therapy

Filipová S

Cardiology Letters 2015, 24(4):230-237  

High blood pressure (BP) as a symptom as well a as clinical disease is caused by multifactorial processes, e.g. on the basis of various pathophysiological "error" events in maintaining the physiological blood flow regulation. Treatment of hypertension may therefore be effective and long-term efficient only if it affects synchronously the many disturbed regulatory areas which maintain the normal function of the cardiovascular (CV) system (heart, central and peripheral arteries) and various other organs (especially kidneys and central nervous system). The vast majority of hypertensive patients require a combination of at least two antihypertensive agents...

Hyperuricaemia and clinical relation: heart, kidney and blood vessels

Lietava J

Cardiology Letters 2015, 24(4):238-242  

Uric acid (UA) in its physiological range represents the most important antioxidative mechanism in humans. Hyperuriacemia (HUA) is a severe pro-oxidative factor which is either associated with or causally related to several cardiac or renal diseases. HUA probably causally contributes to development of hypertension in younger patients or in early stages of hypertension, in which decrease of UA may exhibit an inconsistent hypotensive effect. In stroke patients UA level also has significant prognostic value. UA correlates with diagnostics and severity as well as prognosis of ischemic heart disease. In patients with chronic renal diseases the HUA ≥...

2014 ESC/ESA Guidelines on non-cardiac surgery: cardiovascular assessment andmanagement

The Joint Task Force on non-cardiac surgery: cardiovascular assessment and management of the European Society of Cardiology (ESC) and the European Society of Anaesthesiology (ESA)

Cardiology Letters 2015, 24(4):261-303