Cardiology Letters, 2014 (vol. 23), issue 1

What is the benefit of new guidelines for the diagnosis and therapy of hypertenzion? Comment on 2013 ESH/ESC guidelines for the management of arterial hypertension

Filipová S, Dukát A, Škultétyová D

Cardiology Letters 2014, 23(1):5-9  

Paraoxonase 1 and its effect on myocardial graft rejection in patients after heart transplantation

Sýkora P, Halčák L, Gonçalvesová E, Varga I, Gbelcová H, Repiská V

Cardiology Letters 2014, 23(1):17-25  

Can we improve cardiovascular prognosis by further intervention of serum LDL cholesterol level?

Murín J

Cardiology Letters 2014, 23(1):26-29  

Rarity complication of pacemaker implantation

Čaprnda M, Gašpar Ľ

Cardiology Letters 2014, 23(1):30-33  

Pacemaker implantation is associated with some unavoidable risks and complications, which can happen during the perioperative phase (early complications) but also later (late complications). The incidence of pacemaker complications increases with the amount of implanted devices and with the increasing complexity of the implanted systems. The impact of these complications can be very serious - increase in morbidity, mortality and a decrease of the patient's quality of life. The presented case report describes a 61-year old female patient with transcutaneous perforation of the right breast by a pacemaker lead. This perforation was only resolved 7 months...

Omega-3 polyunsaturated fatty acids affect arrhythmogenic factors and attenuate susceptibility of the heart to malignant arrhythmias in an experimental model of human essential hypertension

Radošinská J, Bačová B, Knezl V, Beňová T, Zurmanová J, Soukup T, Arnoštová P, Slezák J, Gonçalvesová E, Tribulová N

Cardiology Letters 2014, 23(1):10-16  

Objective: Hypertension-induced myocardial remodelling is known to be associated with increased risk of malignant arrhythmias and alterations in electrical coupling protein, connexin-43 (Cx43), may be involved in the pathogenesis. We investigated whether omega-3 fatty acids intake affects abnormalities of Cx43 as well as protein kinase C (PKC) signalling and myosin heavy chain (MyHC) profile at the early and late stage of hypertension in the context of the heart's susceptibility to ventricular fibrillation and ability to restore sinus rhythm. Methods: Untreated young and old male spontaneously hypertensive rats (SHRs) and age-matched normotensive rats...