Official journal of the Slovak Society of Cardiology,
Slovak Society of Hypertension and Slovak Association for Cardiac Arrhythmias

Cardiology Letters 2024, 33(5):295-304

Management of patients with heart failure. Experience from a single centre

Peter Snopek1, 2, Jozef Hasilla1, 2, Dušan Oravec1, Milan Klačanský1, Rastislav Gnyp1, Jakub Benko1, 3
1 Kardiologická klinika FN Nitra
2 Fakulta sociálnych vied a zdravotníctva, Univerzita Konštantína Filozofa Nitra
3 1. Interná klinika, Univerzitná nemocnica Martin, Slovenská republika

The work aimed to evaluate the clinical, laboratory, and echocardiographic characteristics, and the treatment of patients hospitalized for heart failure (HF) at the Cardiology Clinic of University Hospital Nitra in the period from 1.7. until 30.9.2023.

Method: A retrospective analysis of patients hospitalized due to HF at the Cardiology Clinic of University Hospital Nitra from July 1, 2023, to September 30, 2023.

Results: The most frequent cause of hospitalization was a decompensation event of chronic HF (78%). The most common cause of HF was ischemic etiology (less than 40% of patients). In terms of comorbidities, the most common was arterial hypertension (AH) (97.6% of patients hospitalized for HF had AH in the pre-disease). The heart failure phenotype with preserved ejection fraction (HFpEF) predominated (81 patients). The average EF was 44.67%. The most common valvular disease was severe tricuspid regurgitation in 51 patients (29%), followed by severe mitral regurgitation in 43 patients (24%). The mean entry NTproBNP value was 10,299 pg/ml. In total, RAAS inhibitors were included in the medication of 93% of patients. 92% of patients were treated with BB, 72% with SGLT2 inhibitors, 48% with MRA. ACEIs significantly shortened the time required for i.v. diuretic administration (p=0.008).

Conclusion: From the retrospective analysis of the data of patients hospitalized for HF, patients with an ischemic cause and with a decompensatory HF event dominate. The most frequent comorbidity is AH, the HFpEF phenotype being the most frequent. We have documented a fair representation of basic groups of pharmaceuticals with confirmed prognostic significance.

Keywords: heart failure; laboratory results; echocardiography; treatment

Published: May 1, 2024  Show citation

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Snopek P, Hasilla J, Oravec D, Klačanský M, Gnyp R, Benko J. Management of patients with heart failure. Experience from a single centre. Cardiology Letters. 2024;33(5):295-304.
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References

  1. McDonagh TA, Metra M, Adamo M, Gardner RS, Baumbach A, Böhm M, et al. 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur Heart J. 2021;42:3599-3726. Go to original source...
  2. McDonagh TA, Metra M, Adamo M, Gardner RS, Baumbach A, Böhm M, et al. 2023 ESC Scientific Document Group. 2023 Focused Update of the 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur Heart J. 2023;44:3627-3639. Go to original source...
  3. McMurray JJ, Packer M, Desai AS, Gong J, Lefkowitz MP, Rizkala AR, et al.; PARADIGM-HF Investigators and Committees. Angiotensin-neprilysin inhibition versus enalapril in heart failure. N Engl J Med. 2014;371:993-1004. Go to original source...
  4. Bahit MC, Kochar A, Granger CB. Post-Myocardial Infarction Heart Failure. JACC Heart Fail. 2018;6:179-186. Go to original source...
  5. Paolillo S, Dell'Aversana S, Esposito I, Poccia A, Perrone Filardi P. The use of β-blockers in patients with heart failure and comorbidities: Doubts, certainties and unsolved issues. Eur J Intern Med. 2021;88:9-14. Go to original source...
  6. Self T, Soberman JE, Bubla JM, Chafin CC. Cardioselective betablockers in patients with asthma and concomitant heart failure or history of myocardial infarction: when do benefits outweigh risks? J Asthma. 2003;40:839-845. Go to original source...
  7. McMurray JJV, Solomon SD, Inzucchi SE, Køber L, Kosiborod MN, Martinez FA, et al. DAPA-HF Trial Committees and Investigators. Dapagliflozin in Patients with Heart Failure and Reduced Ejection Fraction. N Engl J Med. 2019;381:1995-2008. Go to original source...
  8. Packer M, Anker SD, Butler J, Filippatos G, Pocock SJ, Carson P, et al. EMPEROR-Reduced Trial Investigators. Cardiovascular and Renal Outcomes with Empagliflozin in Heart Failure. N Engl J Med. 2020;383:1413-1424. Go to original source...
  9. Anker SD, Butler J, Filippatos G, Ferreira JP, Bocchi E, Böhm M, et al. EMPEROR-Preserved Trial Investigators. Empagliflozin in Heart Failure with a Preserved Ejection Fraction. N Engl J Med. 2021;385:1451-1461. Go to original source...
  10. Solomon SD, McMurray JJV, Claggett B, de Boer RA, DeMets D, Hernandez AF, et al. DELIVER Trial Committees and Investigators. Dapagliflozin in Heart Failure with Mildly Reduced or Preserved Ejection Fraction. N Engl J Med. 2022;387:1089-1098. Go to original source...
  11. Armstrong PW, Pieske B, Anstrom KJ, Ezekowitz J, Hernandez AF, Butler J et al. VICTORIA Study Group. Vericiguat in Patients with Heart Failure and Reduced Ejection Fraction. N Engl J Med. 2020;382:1883-1893. Go to original source...
  12. Kumar A, Avishay DM, Jones CR Shaikh JD, Kaur R, Aljadah M, et al. Sudden cardiac death: epidemiology, pathogenesis and management. Rev Cardiovasc Med. 2021;22:147-158. Go to original source...
  13. https://www.nczisk.sk/Statisticke_vystupy/Tematicke_statisticke_vystupy/Kardiologia/Pages/default.aspx
  14. Goncalvesová E, Danková M. Čo vieme o epidemiológii srdcového zlyhávania na Slovensku a vo svete. Vnitřní lékařství. 2017;64:839-846. Go to original source...
  15. Ziaeian B, Fonarow GC. Epidemiology and aetiology of heart failure. Nat Rev Cardiol. 2016;13:368-378. Go to original source...
  16. Lin Y, Fu S, Yao Y, Li Y, Zhao Y, Luo L. Heart failure with preserved ejection fraction based on aging and comorbidities. J Transl Med. 2021;19:291. Go to original source...
  17. Bavishi A, Patel RB. Addressing Comorbidities in Heart Failure: Hypertension, Atrial Fibrillation, and Diabetes. Heart Fail Clin. 2020;16:441-456. Go to original source...
  18. Bozkurt B, Aguilar D, Deswal, Dunbar SB, Francis GS, Horwich T, et al. Contributory Risk and Management of Comorbidities of Hypertension, Obesity, Diabetes Mellitus, Hyperlipidemia, and Metabolic Syndrome in Chronic Heart Failure: A Scientific Statement From the American Heart Association. Circulation. 2016;134:e535-e578. Go to original source...
  19. Tsigkas G, Apostolos A, Aznaouridis K, Despotopoulos S, Chrysohoou C, Naka KK, et al. Real-world implementation of guidelines for heart failure management: A systematic review and meta-analysis. Hellenic J Cardiol. 2022;66:72-79. Go to original source...
  20. Damman K, Beusekamp JC, Boorsma EM, Swart HP, Smilde TDJ, Elvan A, et al. Randomized, double-blind, placebo-controlled, multicentre pilot study on the effects of empagliflozin on clinical outcomes in patients with acute decompensated heart failure (EMPA-RESPONSE-AHF). Eur J Heart Fail. 2020; 22:713-722. Go to original source...