Cardiology Letters 2020, 29(1):17-25

Cardiac amyloidosis - rare or underdiagnosed?

Danková M, Gonçalvesová E

Kardiologická klinika Lekárská Fakulty UK a Národný ústav srdcových a cievnych chorôb, a. s., Bratislava, Slovenská republika

Amyloidosis is a heterogenous disease consisting of the depositing of proteinous substance (amyloid) in body tissues. Cardiac amyloidosis is characterized by clinically significant extracellular amyloid infiltration of the heart by amyloid. Cardiac involvement represents the most important prognostic factor in AL amyloidosis and thus early diagnosis of amyloid heart disease is most important for further management. Recent clinical research has shown that amyloidosis, particularly TTR, is not so rare as it was thought. This review aims to discuss pathogenesis, manifestation, complex diagnostics and current therapeutic options of amyloidosis with the main focus on amyloid cardiomyopathy, documented in two case-reports.

Keywords: amyloidosis; amyloid cardiomyopathy; diagnostics; therapy

Published: January 1, 2020  Show citation