Cardiology Letters 2017, 26(4):247-253

Prognostic significance of adrenomedullin, galectin-3 and soluble ST2 in heart failure

Huňavý M, Gášpár P, Gonsorčík J

Klinika kardiológie UPJŠ LF a VÚSCH a.s., Košice, Slovenská republika

Heart failure is the leading cause of cardiovascular morbidity, mortality and hospitalization. Clinical symptoms and echocardiographic proof of myocardial dysfunction are critical to establish diagnosis of this syndrome. Biomarkers currently used for diagnosis of heart failure based on the guidelines of the European Society of Cardiology are natriuretic peptides. During the last few years, novel prognostic biomarkers have been extensively studied. Despite their great number, only a few of them have made it into clinical practice. The aim of this review article is to describe the role of adrenomedullin, galectin-3 and soluble ST2, which as markers of myocardial strain, fibrosis and remodelling figure in the guidelines of the American College of Cardiology for risk stratification of patients with acute and chronic heart failure. The complicated and still explored etiopathogenesis of this clinical syndrome is open to new scientific challenges with translation of findings into clinical cardiology. The initial or permissive role of the mentioned biomarkers seems to be attractive in candidates or patients with heart failure of ischemic or non-ischemic etiology, changes of macro and microarchitecture of myocardium with possible generation of arrhythmogenic substrate and their effects on the structure and function of extracardiac tissues and organ systems. Will it be another example of academic practice or of real clinical use? Fig. 3, Ref. 50, online full text (Free, PDF)

Keywords: heart failure; prognosis; adrenomedull; galectin-3; soluble ST2

Published: April 1, 2017  Show citation