Official journal of the Slovak Society of Cardiology,
Slovak Society of Hypertension and Slovak Association for Cardiac Arrhythmias

Cardiology Letters 2017, 26(3):145-163

Mitochondrial cardiology

Gvozdjáková A1, Kucharská J1, Cornélissen G2, Singh RB3, Šimko F4
1 Univerzita Komenského v Bratislave, Lekárska fakulta a UNB, Farmakobiochemické laboratórium III. internej kliniky, Bratislava, Slovenská republika
2 Halberg Chronobiology Center, University of Minnesota, Minneapolis, USA
3 Halberg Hospital and Research Institute, Moradabad, India
4 Univerzity Komenského v Bratislave, Lekárska fakulta a UNB, Ústav Patologickej fyziológie a III. interná klinika, Bratislava, Slovenská republika

Mitochondrial Cardiology is part of Mitochondrial Medicine, which provides a comprehensive view of mitochondrial disease in terms of clinical, metabolic, genetic and pathological information relevant to the diagnosis and treatment of mitochondrial diseases. Mitochondrial cardiology highlights the irreplaceable importance of mitochondria in the heart muscle in terms of generating the required amount of energy in the form of ATP through oxidative phosphorylation and reducing oxidative stress. Mitochondrial respiratory chain complexes - I, III and IV form stable supercomplexes that contribute to the elucidation of the causes of mitochondrial diseases. The dynamics of mitochondria is controlled by processes that regulate mitochondrial dynamics: biogenesis, fission, fusion and mitophagy. In mitochondria, NAD+ - dependent deacylases - sirtuins (SIRT 3, 4 and 5) signalling stress or cell damage are located. Mitochondrial oxidative phosphorylation, and the heart muscle coenzyme Q10 are controlled by circadian and circasemidian rhythms. Supported therapy with coenzyme Q10 in patients with cardiovascular diseases has a significant role in preventing the development of cardiovascular complications, in improving cardiac muscle function in patients waiting for cardiac transplantation. Targeting therapy with coenzyme Q10 is also of potential importance in preventing the onset and development of heart transplant rejection, reducing the cost of hospitalization and treating patients with cardiovascular diseases, and offering prospective cardiologists access to prevention and targeting therapy of heart muscle damaged mitochondrial function.

Keywords: mitochondrial cardiology; supercomplexes; mitochondrial dynamics; sirtuins; chronobiology; coenzyme Q10

Published: March 1, 2017  Show citation

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Gvozdjáková A, Kucharská J, Cornélissen G, Singh R, Šimko F. Mitochondrial cardiology. Cardiology Letters. 2017;26(3):145-163.
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