Official journal of the Slovak Society of Cardiology,
Slovak Society of Hypertension and Slovak Association for Cardiac Arrhythmias

Cardiology Letters 2016, 25(3):185-189

Cardiovascular diseases and miRNA

Rabajdová M1, Urban P1, Špaková I1, Sabol F2, Mareková M1
1 Ústav lekárskej a klinickej biochémie, UPJŠ v Košiciach, Lekárska fakulta, Košice
2 Klinika srdcovej chirurgie UPJŠ LF a VÚSCH, a. s., Košice, Slovenská republika

Micro RNA (miRNA) plays an important role in the pathogenesis of many cardiovascular diseases e.g. cardiac fibrosis, hypertrophy, remodeling and reparation of post-ischemic injury, or myocardial infarction (MI). Several studies associate regulation of the expression of specific miRNAs, or disruption of the functional components of the RNA interference mechanism, with occurrence of diseases of the cardiovascular and circulatory system. This review article summarizes the basic understanding of miRNA biogenesis during organogenesis and physiological expression of specific miRNAs in comparison to their expression in a variety of cardiovascular diseases such as e.g. coronary atherosclerosis and dilated cardiomyopathy. Results of miRNA analyses contribute to the improvement of knowledge about the pathogenesis of cardiovascular diseases at various levels, bring remarkable optimism not only as to the possibility of their usage as diagnostic molecules, but also as therapeutic targets.

Keywords: micro RNA; cardiovascular diseases; myocardium

Published: March 1, 2016  Show citation

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Rabajdová M, Urban P, Špaková I, Sabol F, Mareková M. Cardiovascular diseases and miRNA. Cardiology Letters. 2016;25(3):185-189.
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