Official journal of the Slovak Society of Cardiology,
Slovak Society of Hypertension and Slovak Association for Cardiac Arrhythmias

Cardiology Letters 2012, 21(1):21-25

Microvascular angina pectoris (cardiac syndrome X) and its relation to insulin resistance and metabolic syndrome

Hrnčiar J, Avdičová M, Gábor D, Hrnčiarová M, Chamulová M, Jakubíková K, Kaliská G, Kiková V, Kovář F, Kreze A jr., Lepej J, Okapcová J, Szentiványi M
Interná klinika Nemocnice F. D. Roosevelta v Banskej Bystrici, Slovenská republika

In the examined group of 500 patients subjected to coronary catheterization, 70 cases (14%) presented a "normal" coronary angiogram. This type of angina pectoris is referred to as microvascular angina pectoris (MIV-AP) or cardiac syndrome X (CSX). We detected a prevalence of periclimacteric women with android obesity (4,1 times): in our sample 52% of them showed symptoms of benign hirsutism and suffered from long-term menstrual cycle disorders. In addition, half of of the MIV-AP patients presented in the myocardial SPECT thallium scintigraphy a significant myocardium perfusion defect during a repeated ergometry. In our study of MIV-AP patients, no elevated levels of endothelin-1 (ET-1) were detected in comparison to healthy population or to patients with significat coronary stenosis that could be used as a relevant MIV-AP marker. On the other hand, we were able to prove the presence of insulin resistance by means of four tests (HOMA, FIRI, Quicki and our indirect insulin sensitivity index-NISI) and phenomena of metabolic syndrome or of syndrome of insulin resitence.

Keywords: MIV-A; insulin resistance; prevalence of periclimacteric women

Published: January 1, 2012  Show citation

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Hrnčiar J, Avdičová M, Gábor D, Hrnčiarová M, Chamulová M, Jakubíková K, et al.. Microvascular angina pectoris (cardiac syndrome X) and its relation to insulin resistance and metabolic syndrome. Cardiology Letters. 2012;21(1):21-25.
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