Official journal of the Slovak Society of Cardiology,
Slovak Society of Hypertension and Slovak Association for Cardiac Arrhythmias

Cardiology Letters 2014, 23(3):215-222

Evaluation of carotid artery stiffness and flow-mediated vasodilation in patients with resistant hypertension after renal sympathetic denervation.

Skultetyova D1, Filipova S1, 2, Madaric J1, Chnupa P1, Fridrich V1, Vulev I3, Gocar M, Skultetyova D1, Filipova S, Madaric J, Chnupa P, Fridrich V, Vulev I, Gocar M.
1 Department Cardiology and Angiology, National Institute of Cardiovascular Diseases, Bratislava, Slovakia
2 Slovak Medical University, Faculty of Medicine, Bratislava, Slovakia
3 Department Diagnostic and Interventional Radiology, National Institute of Cardiovascular Diseases, Bratislava, Slovakia

The aim of the study was to determine the effect of catheter-based renal sympathetic denervation (RDN) on office blood pressure (BP). Thereafter we evaluated the effect of BP lowering on carotid artery stiffness and flow-mediated vasodilation (FMD) using ultrasound and echo-tracking during 6 month follow-up. We found significantly improved office systolic BP changes at 1 month after RDN (p=0.023) together with pulse pressure (PP) changes at 6 months follow-up (systolic BP changes: p=0.041; PP changes: p=0.016). Carotid stiffness values stiffness parameter (beta) and pressure-strain elastic modulus (Ep) were significantly reduced (beta: p=0.04; Ep: p=0.03) and arterial compliance (AC) increased (p=0.03), especially 1 and 3 months after RDN. Mean FMD value in cardiac diastole was significantly improved (p=0.01) too. We observed significant relationships between office BP and carotid stiffness values at 6 months follow-up. Using linear regression model the fall in systolic BP>10 mmHg would be associated with decrease of stiffness parameters beta>1.8%, Ep>55.92 kPa and pulse wave velocity (PWV)>0.7 m/s and with an increase of AC>0.009 mm2/kPa. We conclude that the BP lowering effect of RDN was followed by the improvement of structural and functional parameters of artery wall in short-term follow-up study.

Keywords: carotid artery stiffness; flow-mediated vasodilatation; renal sympathetic denervation; resis­ tant hypertension

Published: March 1, 2014  Show citation

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Skultetyova D, Filipova S, Madaric J, Chnupa P, Fridrich V, Vulev I, et al.. Evaluation of carotid artery stiffness and flow-mediated vasodilation in patients with resistant hypertension after renal sympathetic denervation. Cardiology Letters. 2014;23(3):215-222.
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