Cardiology Letters, 2019 (vol. 28), issue 6

Comment on 2018 ESC Guidelines for the management of cardiovascular diseases during pregnancy

Dúbrava J, Korbeľ M

Cardiology Letters 2019, 28(6):197-201  

ESC Guidelines for the management of syncope 2018 Comment on the guidelines

Mitro P

Cardiology Letters 2019, 28(6):202-209  

Cardiotoxicity induced by immune checkpoint inhibitors used in cancer immunotherapy

Országhová Z Jr., Rečková M, Jablonická M, Mladosievičová B

Cardiology Letters 2019, 28(6):210-217  

Immunotherapy represents a major advance in the treatment of cancer. Over the last decade it has revolutionized the clinical management of a wide spectrum of solid and haematological malignancies, even those associated with a very poor prognosis. Immune checkpoint inhibitors (CPI) are monoclonal antibodies directed against checkpoints of the immune response: cytotoxic T-lymphocyteassociated-4 (CTLA-4), programmed cell death protein 1 (PD-1) and its ligand (PD-L1). They block inhibitory signals of T-cell activation and enable them to provide an effective antitumor response. However, the increasing use of immune checkpoint inhibitors has exposed a group...

Importance of hematopoietic stem cells in the pathogenesis and treatment of cardiovascular diseases: the role of extracellular vesicles in the mechanism of their action

Barteková M, Husseinová M, Radošinská J

Cardiology Letters 2019, 28(6):218-226  

Hematopoietic stem cells (HSCs) represent the only source of all blood elements. HSCs are present primarily in the bone marrow, but also in the peripheral blood and umbilical cord blood. As other cell types, HSCs are able to produce extracellular vesicles (EVs). EVs released from the HSCs (or EVs produced by cells derived from HSCs) exert pleiotropic effects in the body: they contribute to the cell-to-cell communication, are proposed to be biomarkers of the condition of the bone marrow, and are also suggested to be potentially used for the prevention and/or treatment of different diseases including cardiovascular. At the same time, these EVs play an...

Alcohol and health

Bada V

Cardiology Letters 2019, 28(6):227-235  

Unexpected etiology of syncope

Novotny P, Panovsky R, Novak M, Novak M, Feitova V

Cardiology Letters 2019, 28(6):236-238  

Brugada syndrome is an autosomal dominant hereditary disease causing ventricular arrhythmias and sudden cardiac death, especially in young and otherwise healthy people. The incidence of this disease in central Europe is quite low, nevertheless we would like to introduce you a case report of a patient treated in our hospital for this disease.

Left ventricular mass: myxoma or thrombus

Artemiou P, Gasparovic I, Hulman M

Cardiology Letters 2019, 28(6):239-241  

In this case report a 43-year-old male patient presented with symptoms of embolic right leg ischemia. Transthoracic echocardiography showed a left ventricular mass present toward the apex attached to the interventricular septum with the presumptive diagnosis of myxoma. He underwent a successful removal of the tumor through the mitral valve via the transeptal approach. Histology showed mixed thrombus. Figure 3, Ref. 24, on-line full text (Free, PDF) www.cardiologyletters.sk

Stretnutie zástupcov centier pre pľúcnu artériovú hypertenziu

Studenčan M, Hricák V†, Hudec M, Kovář F, Hlivák P, Hatala R, Gonçalvesová E

Cardiology Letters 2019, 28(6):242-245