Cardiology Letters, 2016 (vol. 25), issue 2

Comment on 2015 ESC Guidelines for the management of acute coronary syndromes in patients without persistent ST-segment elevation

Studenčan M, Kovář F

Cardiology Letters 2016, 25(2):69-70  

Where is the place of serum high sensitivity troponin T in the early diagnostic of acute myocardial infarction?

Murín J, Hricák V, Kamenský G, Margóczy R, Daňová K

Cardiology Letters 2016, 25(2):79-84  

In cardiovascular morbidity and mortality in Slovakia acute coronory syndromes feature importantly and this information is presented in our SLOVAKS-1 and SLOVAKS-2 registries. They show our diagnostic and treatment practices here and also present prognostic data about these patients. If we want to improve prognosis of these patients, then we need to shorten the diagnostic time period and improve diagnosis of acute myocardial infarction - then such a patient can get optimal treatment earlier. Two clinical studies (APACE and TRAPID-AMI) first developed, and later confirmed, in routine clinical prac­ tice in patients with acute coronary syndrome, a diagnostic...

Circulating microparticles - new risk factor, or biomarker for cardiovascular diseases?

Dukát A, Šimko F

Cardiology Letters 2016, 25(2):85-90  

Microparticles represent the complex of vesicular structures originating from plasmatic membranes of endothelial cells, thrombocytes, erythrocytes, mono-cytes or myofibroblasts. They are released from the daughter cells under various physiological and pathological circumstances in the process of cellular activa­ tion, apopthosis and/or damage. Among the immediate simuli of this release are various humoral factors, shear stress and inflammation, but also the physical load. As they carry cellular antigens and receptors from the cellular parts, they may serve for the intercellular transmission of biological signals and information. During the transmission...

Homozygous familial hypercholesterolaemia and its treatment

Šimurka P, Matejka M, Malinová J

Cardiology Letters 2016, 25(2):91-98  

Homozygous familial hypercholesterolaemia (HoFH) is a life-threatening disease most commonly caused by loss-of-function mutations in both alleles of the LDL receptor gene. As a consequence of impaired LDL-receptor function, untreated total plasma cholesterol levels are typically greater than 13 mmol/l, resulting in premature and progressive atherosclerosis often leading to cardio-cerbrovascular disease before age 20 years and death before age 30 years. The condition is characterised by exceptionally high LDL cholesterol levels, cutaneous and tendon xanthomas, valvular and supravalvular stenosis and accelerated atherosclerosis, often leading to IM or...

Isometric counterpressure manoeuvres in prevention of reflex vasovagal syncope

Müller E, Mitro P

Cardiology Letters 2016, 25(2):99-106  

Vasovagal syncope (VVS) is the most common type of syncope. Patients with frequent recu­ rrences of VVS have significantly reduced quality of life. Pharmacological treatment is limited by lack of efficacy, and incidence of adverse events. Cardiac pacing is reserved for the strictly-selected older patients with cardioinhibitory response and absence of prodromal symptoms based on evidence-based medicine. Isometric counterpressure manoeuvres (ICM) are indicated as first-line treatment in patients with VVS and prodromes. They improve perfusion of the brain during impending syncope due to increase of blood pre­ ssure and cardiac output. They are especially...

2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation

Task Force for the Management of Acute Coronary Syndromes in Patients Presenting without Persistent ST-Segment Elevation of the European Society of Cardiology (ESC)

Cardiology Letters 2016, 25(2):109-151  

Radiofrequency renal sympathetic denervation in patients with resistant arterial hypertension - 12-month follow-up

Maďarič J, Vulev I, Fľak Ľ, Postulková Ľ, Škultétyová D, Maďaričová T, Hladíková D, Tóth M, Vašková J, Drangová E, Mikuláš J, Mistrík A, Chňupa P

Cardiology Letters 2016, 25(2):71-78  

Aims: To evaluate safety and efficacy of percutaneous radiofrequency renal sympathetic denerv­ ation (RDN) in patients with resistant arterial hypertension (AH) in mid-term follow-up. Methods: In the group of 21 patients (age 54±10 years, M:F 13:8) with inadequately controlled AH on ≥3 com­ bination of antihypertensive treatment including diuretics (average office blood pressure (BP) 187/112 mmHg with average number of antihypertensive drugs 7±1), we performed RDN intervention in analgosedation via transfemoral percutaneous approach with the use of RDN Symplicity catheter and EnligHTN catheter. During the 12 months follow-up period...

Iný pohľad na markery endotelovej dysfunkcie ako prediktory gestačnej hypertenzie a preeklampsie

Gaško R

Cardiology Letters 2016, 25(2):107-108