Official journal of the Slovak Society of Cardiology,
Slovak Society of Hypertension and Slovak Association for Cardiac Arrhythmias

Cardiology Letters 2024, 33(3):175-182

Postprandial hypotension - a possible cardiovascular risk factor?

Peter Mitro
1. Kardiologická klinika UPJŠ LF a VÚSCH, a. s., Košice, Slovenská republika

Postprandial hypotension (PPH) is an excessive drop in blood pressure after eating, which can lead to clinical symptoms such as weakness, dizziness, falls, transient ischemic attacks of the central nervous system, angina pectoris or syncope. PPH is defined as a drop in systolic blood pressure (SBP) of 20 mmHg or more within two hours after a meal. PPH is more often observed in older patients, especially with an associated autonomic disorder (patients with diabetes mellitus, renal insufficiency, Parkinson's disease) but also long-lasting hypertension. Pathogenetic mechanisms of PPH include increased splanchnic pooling, impaired sympathetic nervous system, decreased postprandial baroreflex activity, and neurohumoral mechanisms. Attention is currently being paid mainly to the role of intestinal peptides in the development of PPH. Influencing the secretion of intestinal peptides is one of the promising methods for the treatment of postprandial hypotension.

Keywords: postprandial hypotension; syncope; gut peptides; somatostatin; glucagon-like peptide; glucose-dependent insulinotropic peptide

Published: March 1, 2024  Show citation

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Mitro P. Postprandial hypotension - a possible cardiovascular risk factor? Cardiology Letters. 2024;33(3):175-182.
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