Official journal of the Slovak Society of Cardiology,
Slovak Society of Hypertension and Slovak Association for Cardiac Arrhythmias

Cardiology Letters 2019, 28(4):178-183

SynCardia total artificial heart as a bridge to transplant: Current results at the National Institute of Cardiovascular Diseases in Slovakia

Hulman M1, Artemiou P1, Hudec V1, Olejarova I2, Goncalvesova E3
1 Medical Faculty of the Slovak Medical University, National Institute of Cardiovascular Diseases, Clinic of Cardiac Surgery, Bratislava
2 Medical Faculty of the Slovak Medical University, National Institute of Cardiovascular Diseases, Department of Anesthesiology, Bratislava
3 Medical Faculty of the Slovak Medical University, National Institute of Cardiovascular Diseases, Clinic of Cardiology, dept. of Heart Failure, Bratislava, Slovakia

In this case series we present our initial experience with the implantation of the SynCardia total artificial heart (TAH) in three patients, the first of which was the first SynCardia TAH implantation in the Visegrad Four (V4) countries. The first and the third patients, after 195 and 126 days of TAH support respectively, experienced successful heart transplants, while the second patient on postoperative day 11 died due to a ruptured undiagnosed brain aneurysm. Our results show that the SynCardia TAH is an alternative therapy in patients with severe end-stage biventricular heart failure waiting for heart transplantation. It is an intermediate step until the development of genetically modified animal hearts, engineered bioartificial hearts or hearts from induced pluripotent stem cells could replace the failing heart in patients with end-stage heart disease. Tab. 2, Fig. 1, Ref. 27, on-line full text (Free, PDF) www.cardiologyletters.sks.sk

Keywords: biventricular heart failure; total artificial heart; Syncardia TAH; biventricular assist device heart transplantation

Published: April 1, 2019  Show citation

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Hulman M, Artemiou P, Hudec V, Olejarova I, Goncalvesova E. SynCardia total artificial heart as a bridge to transplant: Current results at the National Institute of Cardiovascular Diseases in Slovakia. Cardiology Letters. 2019;28(4-5):178-183.
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    References

    1. Cleveland JC, Naftel DC, Reece TB, et al. Survival after biventricular assist device implantation: an analysis of the interagency registry for mechanically assisted circulatory support database. J Heart Lung Transplant 2011:30:862-869. Go to original source...
    2. Arabia FA, Cantor RS, Koehl DA, et al. Interagency registry for mechanically assisted circulatory support report on the total artificial heart. J Heart Lung Transplant 2018:37:1298-1300. Go to original source...
    3. Copeland JG, Copeland H, Gustafson M, et al. Experience with more than 100 total artificial heart implants. J Thorac Cardiovasc Surg 2012:143:727-734. Go to original source...
    4. Rangwala Z, Banks DA, Copeland JG. Pro: The total artificial heart: Is it an appropriate replacement for existing biventricular assist devices? J Cardiothorac Vasc Anesth 2014:28:836-839. Go to original source...
    5. Morales DLS, Lorts A, Rizwan R, et al. Worldwide experience with the Syncardia total artificial heart in the pediatric population. ASAIO Journal 2017:63:518-519. Go to original source...
    6. Copeland J. Out of hospital total artificial heart patients. Texas Heart Inst J 2010:37:654-655.
    7. Torregosa G, Anyanwu A, Zucchetta F, et al. SynCardia: the total artificial heart. Ann Cardiothorac Surg 2014:3:612-620.
    8. Karimov JH, Gao S, Dessoffy R, et al. Novel technique for airless connection of artificial heart to vascular conduits. J Artif Organs 2017:20:386-389. Go to original source...
    9. Shah KB, Thanavaro KL, Tang DG, et al. Impact of INTERMACS profile on clinical outcomes for patients supported with the total artificial heart. J Card Fail 2016:22:913-919. Go to original source...
    10. Cook JA, Shah KB, Quader MA, et al. The total artificial heart. J Thorac Dis 2015:7:2172-2180.
    11. Kirsch M, Mazzucotelli JP, Roussel JC, et al. Survival after biventricular mechanical circulatory support: does the type of device matter? J Heart Lung Transplant 2012:31:501-518. Go to original source...
    12. National Institute for Health and Care Excellence (2017) Artificial heart implantation as a bridge to transplantation for end-stage refractory biventricular heart failure. Available at https://nice.org.uk/guidance/ipg602(accessed 20 December 2017)
    13. Nguyen A, Pellerin A, Perrault LP, et al. Experience with Syncardia total artificial heart in a Canadian centre. Can J Surg 2017:60:375-379. Go to original source...
    14. Kirsch MEW, Nguyen A, Mastroianni C, et al. Syncardia temporary total artificial heart as bridge to transplantion: Current results at La Pitie Hospital. Ann Thorac Surg 2013:95:1640-1646. Go to original source...
    15. Backes D, van den Bergh W, van Duijn AL, et al. Cerebrovascular complications of left ventricular assist devices. Eur J Cardiothorac Surg 2012:42:612-620. Go to original source...
    16. Latremouille C, Carpentier A, Leprince P, et al. A bioprosthetic total artificial heart for end-stage heart failure: Results from a pilot study. J Heart Lung Transpl 2018:37:33-37. Go to original source...
    17. Joyce DL, Redfield MM, Kushwaha SS, et al. Pulmonary pressure assessment with the total artificial heart. ASAIO Journal 2018:64:e34-e36. Go to original source...
    18. Gohar S, Taimeh ZA, Morgan AJ, et al. Use of remote pulmonary artery pressure monitoring (CardioMEMS System) in total artificial heart to assess pulmonary hemodynamics for heart transplantation. ASAIO journal 2018:64:e75-e77. Go to original source...
    19. Mankad AK, Tang DG, Clark WB, et al. Persistent anemia after implantation of the total artificial heart. J Cardiac Fail 2012:18:433-438. Go to original source...
    20. Spiliopouls S, Guersoy D, Koerfer R, et al. B-type natriuretic peptide therapy in total artificial heart implantation: Renal effects with early initiation. J Heart Lung Transplant 2014:33:6:662-663. Go to original source...
    21. Fox C, Chopski S, Murat N, et al. Hybrid continuous-flow total artificial heart. J Artif Organs 2018:42:500-509. Go to original source...
    22. Goerlich CE, Frazier OH, Cohn WE. Previous challenges and current progress - the use of total artificial hearts in patients with end-stage heart failure. Expert Review of Cardiovascular Therapy 2016:10:1095-1098. Go to original source...
    23. Fukamachi K, Karimov JH, Sunagawa G, et al. Generating pulsatility by pump speed modulation with continuous-flow total artificial heart in awake calves. J Artif Organs 2017:20:381385. Go to original source...
    24. Fukamachi K, Karimov JH, Byram NA, et al. Anatomical study of the Cleveland clinic continuous-flow total artificial heart in adult and pediatric configuration. J Artif Organs 2018:21:383386. Go to original source...
    25. Fukamachi K, Karimov JH, Horvath DJ, et al. Initial in vitro testing of a paediatric continuous-flow total artificial heart. Interact CardioVasc Thorac Surg 2018:26:897-901. Go to original source...
    26. Unthan K, Cuenca-Navalon E, Pelletier B, et al. Driver electronics design and control for a total artificial heart linear monitor. Med Biol Eng Comp 2018:56:1487-1498. Go to original source...
    27. Taylor DA, Frazier OH, Elgalad A, et al. Building a total bioartificial heart: Harnessing nature to overcome the current hurdles. Artif Organs 2018:42:970-982. Go to original source...

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