Official journal of the Slovak Society of Cardiology,
Slovak Society of Hypertension and Slovak Association for Cardiac Arrhythmias

Cardiology Letters 2017, 26(6):336-347

Effect of perivascular adipose tissue on the reactivity of conduit arteries in rats with different predisposition to hypertension

Zemančíková A, Török J
Ústav normálnej a patologickej fyziológie SAV v Bratislave, Slovenská republika

In this study, the effect of perivascular adipose tissue (PVAT) on sympathoadrenergic contractions of conduit arteries was studied in rats with normal and increased blood pressure. The superior mesenteric artery and abdominal aorta were excised from 12-week-old rats of the Wistar-Kyoto (WKY), normotensive strain, spontaneously hypertensive rats (SHR), and borderline hypertensive rats (BHR) derived from cross-breeding SHR females with WKY males, and paired ring preparations with PVAT intact or removed were prepared from these arteries. In normotensive as well as in hypertensive rats, PVAT exhibited an inhibitory effect on contractile responses of mesenteric arteries to exogenous noradrealine. In the mesenteric arteries of WKY, the anticontractile effect of PVAT was observed also during neurogenic contractions evoked by electrical stimulation of perivascular sympathetic nerves; however, it was not significant in BHR and SHR. In the abdominal aorta of any group of rats, PVAT did not significantly influence the contractions to exogenous noradrenaline. The neurogenic contractions of the abdominal aorta from WKY and BHR were significantly increased in the presence of PVAT, possibly due to the higher density of sympathetic nerve endings in the PVAT of this artery. In conclusion, the inhibitory effect of PVAT on sympathoadrenergic contractions is dependent on the density and distribution of sympathetic nerves in the arterial wall, as the sympathetic innervation might also be present in PVAT and it could influence the vasomodulatory action of PVAT. Furthermore, the weaker anticontractile effect of PVAT in the mesenteric arteries from SHR might contribute to their enhanced sensitivity to adrenergic stimuli. Fig. 2, Tab. 1, Ref. 34, online full text (Free, PDF) www.sks.sk

Keywords: perivascular adipose tissue; conduit arteries; sympathetic nervous system; hypertension

Published: June 1, 2017  Show citation

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Zemančíková A, Török J. Effect of perivascular adipose tissue on the reactivity of conduit arteries in rats with different predisposition to hypertension. Cardiology Letters. 2017;26(6):336-347.
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