Cardiology Letters 2024, 33(3):175-182
Postprandiálna hypotenzia - možný kardiovaskulárny rizikový faktor?
- 1. Kardiologická klinika UPJŠ LF a VÚSCH, a. s., Košice, Slovenská republika
Postprandiálna hypotenzia (PPH) je nadmerný pokles tlaku krvi po príjme potravy, ktorý môže viesť k vzniku klinických symptómov, ako sú slabosť, závraty, pády, prechodné ischemické ataky centrálneho nervového systému, angína pektoris alebo synkopa. PPH je definovaná ako zníženie systolického krvného tlaku (STK) o 20 mmHg alebo viac v priebehu dvoch hodín po jedle. PPH sa častejšie pozoruje u pacientov vyššieho veku najmä s pridruženou autonómnou poruchou (pacienti s diabetes mellitus, renálnou insuficienciou, Parkinsonovou chorobou), ale aj dlhotrvajúcou hypertenziou. Patogenetické mechanizmy PPH zahŕňajú zvýšený splanchnický pooling, poruchu sympatikového nervového systému, zníženú aktivitu baroreflexu po príjme potravy a neurohumorálne mechanizmy. Pozornosť sa v súčasnosti venuje najmä úlohe črevných peptidov pri vzniku PPH. Ovplyvnenie sekrécie črevných peptidov patrí k perspektívnym metódam liečby postprandiálnej hypotenzie. Tab. 1, Lit. 46, on-line full text (Free, PDF), www. cardiologyletters.sk
Kľúčové slová: postrandiálna hypotenzia; synkopa; črevné peptidy; somatostatín; glucagon-like peptid; glucose-dependent insulinotropic peptid
Uverejnené: March 1, 2024 Zobraziť citáciu
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