Cardiology Letters 2016, 25(5):353-364

Oxidative stress after pulmonary veins isolation: Deteriorative or protective factor?

Böhm A^1,2, Tóthová L^3,4, Urban L¹, Slezák P⁵, Bacharová L^5,7, Musil P⁶, Cvičela M⁸, Hatala R^1,2

¹ Národný ústav srdcových a cievnych chorôb, a.s., Bratislava

² Lekárská fakulty, Slovenská zdravotnícka univerzita, Bratislava

³ Ústav Molekulárnej biomedicíny, Lekárska fakulta, Univerzita Komenského, Bratislava

⁴ Centra Molekulárnej medicíny, Slovenská akadémia vied, Bratislava

⁵ Lekárská fakulty, Univerzita Komenského, Bratislava

⁶ Farmakologickej fakulty, Univerzita Komenského, Bratislava

⁷ Medzinárodného laserového centra, Univerzita Komenského, Bratislava, Slovenská republika

⁸ NEMOS GROUP, a.s. Nemocnice Sokolov, s.r.o., Sokolov, Česká republika

Introduction: There is a well-known relation between oxidative stress and atrial fibrillation. The aim of our research was to study the relation between the percentage of time spent in atrial fibrillation (AF burden) and concentrations of oxidative stress biomarkers, before and after pulmonary veins isolation (PVI).

Methodology: We included 19 patients (mean age 55±10 years, 4 females and 15 males) with implanted loop recorders unde­ rgoing PVI. Plasmatic concentrations of advanced glycation end-products (AGEs), fructosamine, advanced oxidation protein products and thiobarbituric-acid reacting substances (TBARS) were measured and AF burden was recorded immediately before and 3 months after the PVI. AF burden was also recorded 9 months after the PVI.

Results: Post procedural AGEs concentration significantly nega­ tively correlated with AF burden after 3 months (ρ = -0.63; p<0.01) and 9 months (ρ= -0.5; p = 0.04) respectively, as well as TBARS concentration significantly negatively correlating with AF burden after 9 months (ρ = -0.61; p = 0.01).

Published: May 1, 2016  Show citation